Pedeset godina od otkrića interleukina 1: biologija, patogeneza i terapija
DOI:
https://doi.org/10.13112/pc.1076Ključne riječi:
INTERLEUKIN-1; ANTAGONIST INTERLEUKIN 1 RECEPTORA; NASLJEDNE AUTOINFLAMATORNE BOLESTISažetak
Prošlo je 50 godina od otkrića interleukina 1, ključnog citokina za upalu u imunološkim reakcijama u ljudi, ali i važnog čimbenika u patogenezi brojnih bolesti. Među njima se u posljednjih 25 godina posebno ističu monogenske autoinflamatorne bolesti no i brojne druge obilježene citokinskom olujom. Razvoj lijekova kojima se ciljano blokira IL-1 doveo je do dugotrajne remisije i poboljšane prognoze za mnoge reumatološke bolesti koje su u prošlosti imale značajne komplikacije, a i u nekih i smrtne ishode.
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