Fifty years since the discovery of interleukin 1: bioogy, pathogenesis and therapy
DOI:
https://doi.org/10.13112/pc.1076Keywords:
INTERLEUKIN-1; INTERLEUKIN 1 RECEPTOR ANTAGONOST PROTEIN; HEREDITARY AUTOINFLAMMATORY DISEASESAbstract
It has been 50 years since the discovery of interleukin 1, a key proinflammatory cytokine for immune reactions in humans, but also an important factor in the pathogenesis of numerous diseases. Among them, in the last 25 years, monogenic autoinflammatory diseases have stood out, as well as other diseases associated with a cytokine storm. The development of drugs that target IL-1 has led to long-term remission and improved prognosis for many rheumatological diseases that in the past had significant complications and, in some cases, even fatal outcomes.
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