Management of a newborn infant of a mother colonized with Streptococcus agalactiae (GBS)
DOI:
https://doi.org/10.13112/pc.1244Keywords:
Infant, Newborn; Sepsis; Streptococcus agalactiaeAbstract
Neonatal sepsis remains one of the leading causes of morbidity and mortality in the neonatal
period, despite significant advances in perinatal care. Streptococcus agalactiae (GBS) remains
the most common cause of early-onset sepsis (EOS). Timely identification of pregnant women
colonized with GBS and adequate intrapartum antibiotic prophylaxis (IAP) are key measures in
the prevention of EOS. This article reviews the epidemiology, risk factors, preventive strategies,
and contemporary approaches to the risk assessment and management of newborns whose
mothers are colonized with GBS.
References
1. Shane AL, Sánchez PJ, Stoll BJ. Neonatal sepsis. Lancet.
2017;390:1770-80. doi: 10.1016/S0140-6736(17)31002-4.
2. Stoll BJ, Puopolo KM, Hansen NI, Sánchez PJ, Bell EF, Carlo
WA, et al. Early-onset neonatal sepsis 2015 to 2017, the
rise of Escherichia coli, and the need for novel prevention
strategies. JAMA Pediatr. 2020;174:e200593. doi: 10.1001
/jamapediatrics.2020.0593.
3. Puopolo KM, Lynfield R, Cummings JJ; Committee on Fetus
and Newborn; Committee on Infectious Diseases. Management of infants at risk for group B streptococcal disease. Pediatrics. 2019;144:e20191881. doi: 10.1542/peds.
2019-1881.
4. Verani JR, McGee L, Schrag SJ; Division of Bacterial Diseases, National Center for Immunization and Respiratory
Diseases, Centers for Disease Control and Prevention.
Prevention of perinatal group B streptococcal disease: revised guidelines from CDC, 2010. MMWR Recomm Rep.
2010;59:1-36.
5. Schrag SJ, Zywicki S, Farley MM, Reingold AL, Harrison LH,
Lefkowitz LB, et al. Group B streptococcal disease in the
era of intrapartum antibiotic prophylaxis. N Engl J Med.
2000;342:15-20. doi: 10.1056/NEJM200001063420103.
6. Weston EJ, Pondo T, Lewis MM, Martell-Cleary P, Morin C,
Jewell B, et al. The burden of invasive early-onset neonatal
sepsis in the United States, 2005-2008. Pediatr Infect Dis.
J 2011;30:937-41. doi: 10.1097/INF.0b013e318223bad2.
7. Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW,
Walsh EM, et al. Stratification of risk of early-onset sepsis
in newborns ≥34 weeks’ gestation. Pediatrics. 2014;133:
30-6. doi:10.1542/peds.2013-1689.
8. Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S,
Newman TB, et al. A quantitative, risk-based approach to
the management of neonatal early-onset sepsis. JAMA
Pediatr. 2017;171:365-71. doi: 10.1001/jamapediatrics.
2016.4678.
9. Kaiser Permanente Neonatal Early-Onset Sepsis Calculator [Internet]. Oakland (CA): Kaiser Permanente; [cited
2026 Mar 9]. Available from: https://neonatalsepsiscalculator.kaiserpermanente.org
10. Benitz WE. Adjunct laboratory tests in the diagnosis of
early-onset neonatal sepsis. Clin Perinatol. 2010;37:42138. doi: 10.1016/j.clp.2010.02.004.
11. Polin RA; Committee on Fetus and Newborn. Management of neonates with suspected or proven early-onset
bacterial sepsis. Pediatrics. 2012;129:1006-15. doi: 10.
1542/peds.2012-0541.
12. Cotten CM. Adverse consequences of neonatal antibiotic
exposure. Curr Opin Pediatr. 2016;28:141-9. doi: 10.1097/
MOP.0000000000000338.
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