Specifics of nursing care based on the recognition of toxoallergic reactions to antiepileptic drugs
DOI:
https://doi.org/10.13112/pc.1039Keywords:
HYPERSENSITIVITY; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; COMPREHENSIVE HEALTH CAREAbstract
Toxic-allergic reactions to antiepileptic drugs represent a serious clinical issue in pediatric patients. These reactions can range from mild skin rashes to life-threatening conditions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Timely recognition of the clinical presentation and identification of the causative drug are of utmost importance, as early discontinuation of the offending drug significantly reduces disease progression and the risk of a fatal outcome. In our patient, a maculopapular rash accompanied by lip swelling appeared following the initiation of anticonvulsant therapy with lamotrigine. In addition to medical treatment, nursing care for the boy was complex and highly specific. It was provided by experienced and well-trained nurses following a strict nursing care plan, aiming to prevent infection spread and protect the integrity of the skin and mucous membranes.
References
1. Neubert A, Dormann H, Weiss J, et al. The impact of unlicensed and off-label drug use on adverse drug reactions in paediatric patients. Drug Saf. 2004;27:1059-67. doi: 10.2165/00002018-200427130-00006.
2. Abtahi-Naeini B, Makhmali R, Amini N, Reza Maracy M, Nouri N, Momen T. Antiepileptic Medication-induced Severe Cutaneous Adverse Reactions in Hospitalized Children: A Retrospective Study. Iran J Allergy Asthma Immunol. 2024;23:139-48. doi: 10.18502/ijaai.v23i2.15320.
3. Roujeau JC, Kelly JP, Naldi L, et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med. 1995;333:1600-7. doi: 10.1056/NEJM199512143332404.
4. Garg VK, Buttar HS, Bhat SA, et al. Stevens-johnson Syndrome and Toxic Epidermal Necrolysis: An Overview of Diagnosis, Therapy Options and Prognosis of Patients. Recent Adv Inflamm Allergy Drug Discov. 2023;17:110-20. doi: 10.2174/2772270817666230821102441.
5. Dobry AS, Himed S, Waters M, Kaffenberger BH. Scoring Assessments in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Front Med (Lausanne). 2022;9:883121. doi: 10.3389/fmed.2022.883121.
6. Bootsma HP, Vos AM, Hulsman J, et al. Lamotrigine in clinical practice: long-term experience in patients with refractory epilepsy referred to a tertiary epilepsy center. Epilepsy Behav. 2008;12:262-8. doi:10.1016/j.yebeh.2007.10.004.
7. Brodie MJ, Besag F, Ettinger AB, et al. Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review. Pharmacol Rev. 2016;68:563-602. doi: 10.1124/pr.115.012021.
8. Avery AJ, Anderson C, Bond CM, et al. Evaluation of patient reporting of adverse drug reactions to the UK 'Yellow Card Scheme': literature review, descriptive and qualitative analyses, and questionnaire surveys. Health Technol Assess. 2011;15:1-234, iii-iv. doi: 10.3310/hta15200.
9. Cho YT, Yang CW, Chu CY. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, Viruses, and Immune System. Int J Mol Sci. 2017;18:1243. doi: 10.3390/ijms18061243.
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